Portait picture of Sophia
Hi, I am
Sophia Mädler
Nice to meet you.
I hold a PhD in biochemistry, an MSc in management and have several years of experience in software development and data evaluation for life sciences. I am the lead developer of scPortrait, a Python framework for deep representation learning of single cells from microscopy images. Recently, I developed SPARCS, a genetic screening technology for image-based phenotypes with unprecedented throughput.
Contact
Name
Sophia Clara Mädler
E-mail
hello@sophia-maedler.com
maedler@biochem.mpg.de
Twitter X
@SophiaMaedler
LinkedIn
Sophia Mädler
GitHub
sophiamaedler
Work experience
since Oct 2024
Postdoctoral researcher
Matthias Mann
Proteomics and Signal Transduction
@ Max Planck Institute of Biochemistry
Munich, GER
Sep 2018 - Apr 2019
Internship
Bioinformatics and Exploratory Data Analysis (BEDA)
@ F. Hoffmann La-Roche
Basel, CHE
Education
May 2020 - Oct 2024
PhD Biochemistry
final grade: summa cum laude
@ Ludwig-Maximilians-University Munich

International Max Planck Research School (IMPRS)
Matthias Mann
Proteomics and Signal Transduction
@ Max Planck Institute of Biochemistry
Munich, GER
Oct 2017 - Sep 2023
MSc Management
final grade: 1.5
@ Technical University of Munich

Thesis
Christian Feilcke
Economics of Innovation
@ Technical University of Munich
Munich, GER
Apr 2017 - Mar 2020
MSc Biochemistry
final grade: 1.34
@ Ludwig-Maximilians-University Munich

Thesis
Christina Zielinski
Human T-Cell Immunology
Center for translational Cancer Research (TranslaTUM)
@ Technical University of Munich
Munich, GER
Sep 2013 - Nov 2016
BSc Molecular Biomedicine
final grade: 1.4
@ Rheinische Friedrich-Wilhelms-Universität Bonn

Thesis
Eicke Latz
Institute of Innate Immunity
@ Rheinische Friedrich-Wilhelms-Universität Bonn
Bonn, GER
2009 - 2013
High School
Abitur
final grade: 1.0
@ Sankt Adelheid Gymnasium der Stadt Bonn
Bonn, GER
Grants, Scholarships & Awards
2023
Early Career Researcher Spotlight Award
Life Science Alliance
2021 - 2023
PhD fellowship
Boehringer Ingelheim Fonds
2015 - 2016
Deutschlandstipendium
Other projects & activities
2020
Interact conference
conference organizer
2014 - 2016
iGEM Team Bonn
Silver medal 2016
Publications
Google Scholar
Sophia Mädler
ORCID
0000-0001-7817-4180
Peer-reviewed research
2025
Nature
Deep Visual Proteomics maps proteotoxicity in a genetic liver disease
Rosenberger FA, Mädler SC, Thorhauge KH, Steigerwald S, Fromme M, Lebedev M, Weiss CAM, Oeller M, Wahle M, Metousis A, Zwiebel M, Schmacke NA, Detlefsen S, Boor P, Fabian O, Frankova S, Krag A, Strnad P, Mann M
https://doi.org/10.1038/s41586-025-08885-4
2023
Nature Methods
Spatial single-cell mass spectrometry defines zonation of the hepatocyte proteome
Rosenberger FA, Thielert M, Strauss MT, Schweizer L, Ammar C, Mädler SC, Metousis A, Skowronek P, Wahle M, Madden K, Gote-Schniering J, Semenova A, Schiller HB, Rodriguez E, Nordmann TM, Mund A, Mann M
https://doi.org/10.1038/s41592-023-02007-6
2022
Immunity
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network
Schmacke NA, O’Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, Nagl D, Stafford CA, Harz H, Fröhlich A, Pinci F, Ginhoux F, Beckmann R, Mann M, Leonhardt H, Hornung V
https://doi.org/10.1016/j.immuni.2022.10.021
2022
Science Immunology
Human skin-resident host T cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential
de Almeida GP, Lichtner P, Eckstein G, Brinkschmidt T, Chu CF, Sun S, Reinhard J, Mädler SC, Kloeppel M, Verbeek M, Zielinski CE
https://doi.org/10.1126/sciimmunol.abe2634
2021
Nature
Single-cell delineation of lineage and genetic identity in the mouse brain
Bandler RC*, Vitali I*, Delgado RN*, Ho MC, Dvoretskova E, Ibarra Molinas JS, Frazel PW, Mohammadkhani M, Machold R, Maedler S, Liddelow SA, Nowakowski TJ, Fishell G, Mayer C
https://doi.org/10.1038/s41586-021-04237-0
2021
NAR genomics and
bioinformatics
Besca, a single-cell transcriptomics analysis toolkit to accelerate translational research
Mädler SC, Julien-Laferriere A, Wyss L, Phan M, Sonrel A, Kang ASW, Ulrich E, Schmucki R, Zhang JD, Ebeling M, Badi L, Kam-Thong T, Schwalie PC, Hatje K
https://doi.org/10.1093/nargab/lqab102
Preprints
2025
bioRxiv
In vitro model of human subcutaneous adipocyte spheroids for studying mitochondrial dysfunction and mitochondria activating compounds
Wagner A, Lautaoja-Kivipelto JH, Pehkonen K, Hassinen A, Kuusela M, Röttger L, Herbers E, Ioannidou A, Mädler SC, Rothenaigner I, Srinivasan S, Laasonen S, Rahman MT, Elomaa P, Kortetjärvi S, Olsson A, Ukkola O, Hadian K, Mann M, Peltoniemi H, Pietiläinen KH, Klingenspor M, Virtanen KA, Hagberg CE, Pirinen E
https://doi.org/10.1101/2025.04.16.649074
2023
bioRxiv
SPARCS, a platform for genome-scale CRISPR screening for spatial cellular phenotypes
Schmacke NA*, Mädler SC*, Wallmann G, Metousis A, Bérouti M, Harz H, Leonhardt H, Mann M, Hornung V
https://doi.org/10.1101/2023.06.01.542416